Trials of Influenza A/New Jersey/76 Virus Vaccine in Normal Children: An Overview of Age-Related Antigenicity and Reactogenicity
Identifieur interne : 002A44 ( Main/Exploration ); précédent : 002A43; suivant : 002A45Trials of Influenza A/New Jersey/76 Virus Vaccine in Normal Children: An Overview of Age-Related Antigenicity and Reactogenicity
Auteurs : Peter F. Wright [États-Unis] ; Juliette Thompson [États-Unis] ; William K. Vaughn [États-Unis] ; David S. Folland [États-Unis] ; Sarah H. W. Sell [États-Unis] ; David T. Karzon [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1977.
Abstract
The total multicenter data from trials with inactivated monovalent influenza A/New Jersey/76 virus vaccine in 2,326 normal children were collected and summarized at Vanderbilt University (Nashville, Tenn.). These combined data provided the best measure of the relative antigenicity and reactogenicity of each manufacturer's vaccine. Children younger than 10 years of age were shown to have vaccine-associated reactions to doses of whole-virus vaccine containing as little as 50 chick cell-agglutinating units. Split-virus vaccines were well tolerated in doses eight times as high. No vaccine was satisfactorily antigenic in a single dose. A two-dose regimen of splitvirus vaccine was antigenic, and this regimen was not associated with acute reactions.
Url:
DOI: 10.1093/infdis/136.Supplement_3.S731
Affiliations:
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Sell</name></author><author><name sortKey="Karzon, David T" sort="Karzon, David T" uniqKey="Karzon D" first="David T." last="Karzon">David T. Karzon</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9E09C3B9F104526BC2E226B3175F7511AAF8ABC1</idno><date when="1977" year="1977">1977</date><idno type="doi">10.1093/infdis/136.Supplement_3.S731</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-4PS80CZP-1/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001515</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001515</idno><idno type="wicri:Area/Istex/Curation">001515</idno><idno type="wicri:Area/Istex/Checkpoint">001622</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001622</idno><idno type="wicri:doubleKey">0022-1899:1977:Wright P:trials:of:influenza</idno><idno type="wicri:Area/Main/Merge">002C05</idno><idno type="wicri:Area/Main/Curation">002A44</idno><idno type="wicri:Area/Main/Exploration">002A44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Trials of Influenza A/New Jersey/76 Virus Vaccine in Normal Children: An Overview of Age-Related Antigenicity and Reactogenicity</title><author><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Pediatrics and the Division of Biostatistics, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Peter F. Wright, Department of Pediatrics, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, Juliette" sort="Thompson, Juliette" uniqKey="Thompson J" first="Juliette" last="Thompson">Juliette Thompson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Pediatrics and the Division of Biostatistics, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Vaughn, William K" sort="Vaughn, William K" uniqKey="Vaughn W" first="William K." last="Vaughn">William K. Vaughn</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Pediatrics and the Division of Biostatistics, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Folland, David S" sort="Folland, David S" uniqKey="Folland D" first="David S." last="Folland">David S. Folland</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Pediatrics and the Division of Biostatistics, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Sell, Sarah H W" sort="Sell, Sarah H W" uniqKey="Sell S" first="Sarah H. W." last="Sell">Sarah H. W. Sell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Pediatrics and the Division of Biostatistics, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Karzon, David T" sort="Karzon, David T" uniqKey="Karzon D" first="David T." last="Karzon">David T. Karzon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Pediatrics and the Division of Biostatistics, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1977-12">1977</date><biblScope unit="vol">136</biblScope><biblScope unit="issue">Supplemet_3</biblScope><biblScope unit="page" from="S731">S731</biblScope><biblScope unit="page" to="S741">S741</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The total multicenter data from trials with inactivated monovalent influenza A/New Jersey/76 virus vaccine in 2,326 normal children were collected and summarized at Vanderbilt University (Nashville, Tenn.). These combined data provided the best measure of the relative antigenicity and reactogenicity of each manufacturer's vaccine. Children younger than 10 years of age were shown to have vaccine-associated reactions to doses of whole-virus vaccine containing as little as 50 chick cell-agglutinating units. Split-virus vaccines were well tolerated in doses eight times as high. No vaccine was satisfactorily antigenic in a single dose. A two-dose regimen of splitvirus vaccine was antigenic, and this regimen was not associated with acute reactions.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></region><name sortKey="Folland, David S" sort="Folland, David S" uniqKey="Folland D" first="David S." last="Folland">David S. Folland</name><name sortKey="Karzon, David T" sort="Karzon, David T" uniqKey="Karzon D" first="David T." last="Karzon">David T. Karzon</name><name sortKey="Sell, Sarah H W" sort="Sell, Sarah H W" uniqKey="Sell S" first="Sarah H. W." last="Sell">Sarah H. W. Sell</name><name sortKey="Thompson, Juliette" sort="Thompson, Juliette" uniqKey="Thompson J" first="Juliette" last="Thompson">Juliette Thompson</name><name sortKey="Vaughn, William K" sort="Vaughn, William K" uniqKey="Vaughn W" first="William K." last="Vaughn">William K. Vaughn</name><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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